A series of novel 1-substituted 7-azaisatin derivatives synthesized from 7-azaindole by oxidation with N bromosuccinamide further involves incorporation of isonicotino- hydrazide with 7-aza isatin then treated with various alky halides to give titled compounds and screened for antimicrobial activity. In view of the antimicrobial property of this pharmacophore it was visualized that its combined effect with an active moiety may result in increased antimicrobial activity. All the synthesized titled compounds exhibited excellent to moderate antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Proteus vulgaris, Escherichia coli and two fungal strains Candida albicans, Aspergillus niger.
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